Partner 1. (Coordinator) University of Lodz (UL)

UL - is in a possession of , well-equipped labs having besides standard laboratory utilities also more sophisticated equipment like: electron paramagnetic resonance spectrometer, differential scanning calorimetry, isothermal titration calorimetry, capillary electrophoresis, circular dichroism, zetasizer Nano ZS, Real Time PCR, flow cytometry, COMET assay, ELISA, gel-electrophoresis, fluorimetry, transmission electron microscope, fluorescent and confocal microscopes and other techniques.

Relevant expertise: 
Prof. Maria Bryszewska is an expert in the field of the application of dendrimers for medical treatment in Alzheimer and prion diseases, for genetic material delivery and the application of dendrimers for detoxication. She is a member of various international and European scientific societies, an author or co-author of over 290 articles in refereed journals, 2 books and 14 chapters in books, and the organizer of several international conferences. She has over 35 years of teaching experience and was a supervisor of 15 Ph.D. theses. H-index 39.
Dr. Katarzyna Milowska has adequate expertise in studying dendrimers for biomedical applications and their potential use as antiamyloid agents, drug and gene carriers. Ph.D., Assistant professor at the University of Lodz. She is an author or co-author 42 articles in refereed journals. H-index 11.
Dr. Maksim Ionov is an expert in the field of the application of nanoparticles in drug/gene delivery and potential use of nanotechnology in medicine. He studies the role of oxidized lipid systems in aggregation processes of amyloid peptides in the presence/absence of glycosaminoglycans. Ph.D., Associate professor at the Department of General Biophysics, Lodz University. He is a co-author of 4 book chapters and over 70 articles in journals, H-index 20. 
Dr. Elzbieta Pedziwiatr-Werbicka has considerable expertise in nanoparticles (dendrimers and AuNPs) and their complexes with gene material, transfection of these complexes into cells, anti-HIV therapy using biophysical methods. She is a co-author of 4 book chapters and over 24 articles in journals, H-index 15. 
Dr. Aneta Balcerczyk is an expert in epigenetic regulation of endothelial cell biology; effect of histone methylation/acetylation status on angiogenesis process; inflammatory response of endothelial cells; redox balance; oxidative stress; hyperglycemia / diabetes / ketone bodies. She is co-author of: 2 chapters in books; 41 papers in peer-reviewed journals; 58 communications to scientific meetings; H-index - 17; IF = 164.19; Citations without self-citations - 1107.
Partner 2. University of Alcala (UAH)

UAH - all necessary characterization equipment for structural analysis is available in the laboratories at UAH and the Centers for Support of Research. Examples of available techniques are Nuclear Magnetic Resonance spectroscopy, X-ray diffraction, chemistry and microbiology analysis, mass spectrometry, Differential Scanning Calorimetry, Dynamic Light Scattering, Size Exclusion Chromatograpy, UV-Vis and IR, etc. 
Relevant expertise: 
Prof. F. Javier de la Mata leads the field in the synthesis and use of carbosilane dendritic materials in biomedical applications. Experienced in the direction of Research projects funded by the Spanish Government and European Entities. He is co-author in over 160 articles in high-impact journals, 18 patents, 7 chapters in books, supervisor of 11 PhD thesis and cofounder of two spin-off biotechnological companies. H-index: 24. 
Dr. Paula Ortega is an expert in the synthesis of dendritic systems (dendrimers and dendrons) to use them in different biomedical applications such as drug delivery systems, antiviral or anticancer agents. She is currently a CIBER-BBN postdoctoral researcher in University of Alcala. She is co-author of 4 book chapters and over 30 articles in refereed journals. H-index: 16. 
Dr. Sandra García-Gallego is a young researcher with broad expertise in the synthesis, characterization and biomedical evaluation of dendritic nanoparticles, including tissue adhesives, antiviral, antibacterial and antitumoral agents. She is coauthor in 19 scientific publications and co-editor in a RSC monograph. Her interest in the knowledge-transfer to industry is reflected in her 3 patents and her involvement in the SMEs Biomedical Bonding AB. H-index: 10. 
Ms. Natalia Sanz del Olmo, PhD student working on the synthesis of ruthenium metallodendrimers as antitumoral agents.
Partner 3. Riga Stradiņš University (RSU)

RSU - hosts pathology lab with IHC and FISH/CISH facilities, and has an access to the wide array of laboratory technologies of the university, including standard approaches in proteomics (Western blot, ELISA), genomics (Illumina HiScan SQ with mRNA module; RT-PCR; sequencing ABIPrism 3100); full scale electronic microscopy with transmission and scanning units; microscopy including fluorescence and confocal microscopy. Partner has unique expertise in light microscopy, immunohistochemistry, computer-assisted morphometry, digital morphometry and transmission electron microscopy, and unique capacity and expertise to explore the complicated cascade of endothelial-based events in the neurovascular unit. 
Relevant expertise:
Prof., MD, PhD Ilze Strumfa is a board-certified expert in pathology with 16-year-long experience in histopathological diagnostics and differential diagnostics covering broad spectrum of pathologies as well as in IHC, TEM, polarisation and fluorescence microscopy. She is an author/co-author of 77 peer-reviewed articles in journals and 14 chapters in scientific monographs and medical textbooks. She has 10 years of teaching experience, has supervised 9 PhD students and introduced digital pathology in RSU. Prof. Strumfa has been the leading expert-pathologist in European Structural fund (ESF) projects H-index 6. 
Asoc. prof., MD, PhD Arnis Abolins is a young researcher (PhD: 2013) and board-certified expert in pathology, including histopathological diagnostics, neuropathology, IHC, TEM, polarisation and fluorescence microscopy. He is a member of several local and European scientific societies, an author/ co-author of 29 peer-reviewed articles in medical journals and 2 chapters in scientific monographs. He has 8 years of teaching experience, has supervised 2 PhD students and has contributed his expertise to ESF projects. H-index 3. 
Assoc. Prof, PhD Maria Issagouliantis (Isaguliants), PhD 1992; docent in immunology at Karolinska Institutet, Stockholm, Sweden, 2007. Maria is an expert in animal experimentation, and animal models of chronic human diseases, both viral infections, and cancer. Lately has focused in the role of oxidative stress in the development of human pathologies. Supervised 5 PhD studies, and multiple BSi and MSci studies at Karolinska Institutet, Stockholm, Latvian University, Riga and Lomonosov State University, Moscow. Member of the Steering Board of International Society for Vaccines, Member of Editorial Board of open access research journals “Oxidative Stress and Cellular Longevity”, “Vaccines” and “Acta Naturae”. Author of over 70 publications, H-index 16.
Partner 4. Latvian Biomedical Research and Study Centre (LBMC)
LBMC - is the leading scientific institute in molecular biology and biomedicine in Latvia. As a coordinator and key participant of several national research programmes in biomedicine (infectious diseases, human genome research, ageing population). The animal facility is equipped with in vivo imaging system IVIS Spectrum (Perkin-Elmer). The laboratory block is equipped with fluorescent and confocal microscopes, flow cytometer/sorter FACS Aria II and the transmission electron microscope JEOL JEM-1230. Partner has unique facility for animal experimentation, and personal highly qualified to accomplish the tasks f modelling IS and AD in rodents. 
Relevant expertise: 
Dr. Juris Jansons, LBMC team leader, is the researcher with broad expertise in molecular biology, cell biology, experimental immunology and optical detection of biomolecules. In 2018 he has completed course in Laboratory Animal Science Function A (Rodents and Lagomorphs) at LAS E&T Unit at Comparative Medicine, Karolinska Institutet. Have participated in Horizon 2020, European Structural fund and Latvian Council of Science projects. Number of publications 13. SCOPUS Hirsh index 6. 
Dr. Dace Skrastina has extensive experience and exceptional skills in working with various laboratory animals, with data analysis and immunological tests; wide knowledge in working with cell (animal-, human-) cultures. Dr. Skrastina got the category "C" of the FELASA to work with laboratory animals, in accordance with the rules of Norwegian College of Veterinary medicine. Number of publications 29. SCOPUS Hirsh index 18.

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